Continuous Cell Expansion and Harvest System

Continuous Cell Expansion and Harvest System

Rollup - logo
Company
Ivy Farm TechnologiesIvy Farm Technologies
Technology Pitch

A combined seed train and media exchange system that uses chemostats and gravitational settling to maintain exponential cell growth with minimal labor and damage. Ideal for scaling cultivated meat production efficiently.

Potential Users

Cultivated meat producers requiring scalable, low-labor, and efficient systems for cell expansion and harvesting to feed larger production bioreactors.

Application Conditions

Best suited for suspension-adapted mammalian cells with aggregation propensity; optimal in controlled, sterile environments with long-term operation and minimal intervention.

Key Benefits

• Maintains cells in exponential growth phase for optimal harvesting • Reduces labor and contamination risk via closed-loop operation • Enables continuous, scalable cell expansion • Gentle media exchange reduces cell damage compared to centrifugation • Supports consistent cell density and nutrient levels over time

Unique Features

• Use of chemostat, turbidostat, or auxostat with adjustable dilution rates • Gravitational settling for “light partial harvest” without centrifugation • Integrated dip-tube for precise media removal post-settling • Compatible with biomass/metabolite/timer-based control systems • Designed for both small and large-scale bioreactors (1–50,000L)

Featured
Active
Problem Solved
Long culture timesCell damage during harvestManual handling bottlenecksContamination riskUnscalable bioreactor designLack of process monitoringHigh energy inputInefficient nutrient deliveryInconsistent batch quality
Tech Category
Bioprocess Optimization
patent

WO2025062138A2