A combined seed train and media exchange system that uses chemostats and gravitational settling to maintain exponential cell growth with minimal labor and damage. Ideal for scaling cultivated meat production efficiently.
Cultivated meat producers requiring scalable, low-labor, and efficient systems for cell expansion and harvesting to feed larger production bioreactors.
Best suited for suspension-adapted mammalian cells with aggregation propensity; optimal in controlled, sterile environments with long-term operation and minimal intervention.
• Maintains cells in exponential growth phase for optimal harvesting • Reduces labor and contamination risk via closed-loop operation • Enables continuous, scalable cell expansion • Gentle media exchange reduces cell damage compared to centrifugation • Supports consistent cell density and nutrient levels over time
• Use of chemostat, turbidostat, or auxostat with adjustable dilution rates • Gravitational settling for “light partial harvest” without centrifugation • Integrated dip-tube for precise media removal post-settling • Compatible with biomass/metabolite/timer-based control systems • Designed for both small and large-scale bioreactors (1–50,000L)